Screening of TP53 mutations by DHPLC and sequencing in brain tumours from patients with an occupational exposure to pesticides or organic solvents
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چکیده
منابع مشابه
Dementia and occupational exposure to organic solvents.
OBJECTIVES To investigate whether occupational exposure to organic solvents increases the risk of dementia. METHODS Cases of dementia were identified from the computed tomography records of eight neuroradiology centres in England and Wales, and were compared with two sets of controls investigated at the same centres. The first set of controls were patients with brain cancer and the second set...
متن کاملOccupational exposure to organic solvents and breast cancer in women.
BACKGROUND Although studies in rodents suggest possible associations between exposure to organic solvents and breast cancer, the evidence in humans is limited. METHODS We evaluated job histories of 2383 incident breast cancer cases diagnosed during 2000-2003, and 2502 controls who participated in a large population-based case-control study in Poland. Industrial hygienists reviewed occupationa...
متن کاملOccupational exposure to organic solvents and K-ras mutations in exocrine pancreatic cancer.
Occupational exposure to hydrocarbon solvents has been found to be associated with an increased risk of exocrine pancreatic cancer (EPC), the human tumor with the highest prevalence of K-ras mutations. Ras genes are critical DNA targets for chemical carcinogens. We analysed the relationship between past occupational exposure to hydrocarbon solvents and mutations in codon 12 of the K-ras gene in...
متن کاملExposure to pesticides or solvents and risk of Parkinson disease.
OBJECTIVE To investigate the risk of Parkinson disease (PD) associated with exposure to pesticides and solvents using meta-analyses of data from cohort and case-control studies. METHODS Prospective cohort and case-control studies providing risk and precision estimates relating PD to exposure to pesticides or solvents or to proxies of exposure were considered eligible. The heterogeneity in ris...
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ژورنال
عنوان ژورنال: Mutagenesis
سال: 2005
ISSN: 1464-3804,0267-8357
DOI: 10.1093/mutage/gei052